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. 2014 Dec 16;10:1–11. doi: 10.2147/CIA.S72521

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© 2015 Guerriero et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Distribution of prolonged-release oxycodone–naloxone (OXN-PR) daily dosages throughout the observation (expressed in oxycodone-equivalents). The 15 mg daily dosage was two 5/2.5 mg tablets in the morning and one in the evening, or vice versa, according to individual need and pain characteristics (three patients at day 7 [T7], one at day 14 [T14], and one at day 28 [T28]). There were two women (aged 75 and 80 years) who, after a few days of the new treatment, reduced their OXN-PR daily doses to only one 5/2.5 mg tablet in the morning because of drowsiness; in the following weeks, both increased their OXN-PR daily dose to 20/10 mg without major side effects. Two other women with severe knee pain due to osteoarthritis at the last follow-up visit had decreased their daily OXN-PR to one 5/2.5 mg tablet in the morning, nevertheless with satisfactory pain control.