Table 2.

Change in pain intensity (Numeric Rating Scale score) during the 28-day observation of oxycodone/naloxone prolonged-release treatment

Parameter	Baseline	Day 7	Day 14	Day 28	Analysis of variance P-value*
Pain at rest, mean	5.9±1.9	4.6±1.6†	3.9±1.8	2.9±1.7#	<0.0001
Pain on movement, mean	8.0±0.9	6.3±1.6¶	5.3±1.9#	4.3±2.0#	<0.0001
Daytime pain, mean	7.5±1.0	5.9±1.7¶	5.0±2.1	3.9±2.3†	<0.0001
Nocturnal pain, mean	5.4±2.1	4.2±2.0#	3.5±2.1	2.5±1.9^	<0.0001

Notes: Included in this analysis were all patients completing the 28-day treatment (n=52).

^*Day 28 vs baseline

^{^}P<0.01 vs previous observation

^#P<0.01 vs previous observation

^†P<0.005 vs previous observation

^¶P<0.0001 vs previous observation.