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. 2014 Dec 18;15(1):409. doi: 10.1186/s12859-014-0409-8

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© Gomez et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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DyMMM simulation results of example 2. DyMMM is unable to simulate Example 2. Computation time for one hour of simulation was of more than 3900 seconds using MATLAB integrator ode45. In addition, the acetate curve has several points of nonsmoothness that can be explained by the presence of nonunique fluxes. Numerical integrators are unable to integrate these kinds of systems.