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. 2014 Dec 14;33(1):105. doi: 10.1186/s13046-014-0105-6

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© Du et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Brachyury enhances metastatic potential of HCC cells. (A) The invasive properties of the cells were analyzed in by an invasion assay using a Matrigelcoated Boyden chamber. Migrated cells were plotted as the average number of cells per field of view from 3 different experiments, as described in Materials and Methods. (B) The cell migration rate between SMMC-7721/Brachyury and SMMC-7721/GFP cells was compared by wound-healing assay. Microscopic observation was recorded at 0 and 24 hours after scratching the cell layer. (C) Representative view of lung tissue sections from each group are shown (H&E stain; magnification × 100). The number of lung metastatic foci in each group (n = 10) of HepG2/Brachyury or HepG2/GFP xenografted mice was calculated microscopically 6 weeks after tail vein injection. *p < 0.05.