Figure 6.

The roles of Adam10 in determination of collecting duct cell fate appear to be largely fulfilled prenatally. As early as E17.5, there were more ATPase⁺ ICs in the mutants (60.7%±7.5% for PCs, 39.3%±7.1% for ICs) (B) than in controls (74.8%±4.7% for PCs versus 25.2%±4.6% for ICs) (A) in the kidney inner medulla. The ratio of ATPase⁺ ICs to Aqp2⁺ PCs was increased in the E17.5 mutants (C). An increase in the number of Foxi1⁺ cells in the mutants was also observed as early as E17.5 (D and E). CT, controls; MT, mutants. Original magnification, ×20 in A and B; ×40 in D and E.