Skip to main content
. 2014 Jun 12;26(1):133–147. doi: 10.1681/ASN.2013111213

Figure 9.

Figure 9.

ASMase inhibitors (AIs) ameliorate the phenotype in a mouse model for DKD. (A) Urine albumin (Alb)-to-creatinine ratio is significantly higher in db/db mice compared with db/m mice (**P<0.01), and AI treatment significantly abrogates proteinuria in db/db mice compared with untreated db/db mice (#P<0.05). (B) Glomerular surface area is increased in db/db mice compared with db/m mice (*P<0.05); however, glomerular surface area is significantly smaller in ASMase-treated db/db mice compared with untreated db/db mice (#P<0.05) and seems to not be significantly changed compared with db/m mice. (C) Glomerular cleaved caspase-3 expression is significantly higher in db/db mice compared with db/m mice (*P<0.05), and expression is significantly reduced by AI treatment (#P<0.05). GAPDH, glyceraldehyde-3-phosphate dehydrogenase. (D) Glomerular active RhoA expression is increased in db/db mice (**P<0.01) and attenuated by AI treatment (#P<0.05). MFI, mean fluorescence intensity.