Figure 3.

Small-molecule inhibitor ICG-001 ameliorates an established proteinuria and kidney injury in ADR nephropathy. (A) Diagram shows the experimental design. Arrows indicate the starting point of ADR injection. Green bars indicate ICG-001 treatment. (B) Urinary albumin levels in mice at 5 weeks after ADR injection. Urinary albumin was expressed as milligrams per milligram creatinine. (C) Representative micrographs show kidney injury at 5 weeks after ADR injection in different groups of mice as indicated. Images of periodic acid–Schiff staining with different magnifications are shown. Scale bar, 50 µm. (D) Quantitative determination of kidney fibrotic lesions in different groups. Ctrl, control. *P<0.05 versus normal controls; ^†P<0.05 versus ADR alone (n=5–6).