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. 2014 Jul 10;26(1):107–120. doi: 10.1681/ASN.2014010085

Figure 4.

Figure 4.

Inhibition of β-catenin signaling by ICG-001 abolished RAS induction in ADR nephropathy. (A) Representative Western blot analyses revealed that ICG-001 abolished RAS induction in ADR nephropathy. Kidney lysates from different groups as indicated were immunoblotted with antibodies against AGT, renin, ACE, AT1, and actin. Numbers 1 and 2 represent different animals in a given group. (B–E) Graphic presentations of the relative abundances of (B) AGT, (C) renin, (D) ACE, and (E) AT1 in different groups as indicated. *P<0.05 versus normal controls; †P<0.05 versus ADR (n=5–6). (F) Representative micrographs showed RAS components in different groups as indicated. Kidney sections were stained with different antibodies against AGT, renin, ACE, and AT1. Arrows indicate positive tubules. Ctrl, control. Scale bar, 50 µm.