Table 2.
Tissue distributions of differently sized silica nanoparticles in rats after a single oral administration
| Control
|
500 mg/kg
|
1,000 mg/kg
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Male | Female | 20 nm
|
100 nm
|
20 nm
|
100 nm
|
|||||
| Male | Female | Male | Female | Male | Female | Male | Female | |||
| Brain (μg/g) | 104±7 | 103±8 | 109±3 | 105±16 | 104±10 | 97±3 | 107±10 | 93±14 | 107±8 | 100±9 |
| Kidneys (μg/g) | 90±7 | 80±11 | 144±6* | 131±9* | 132±18* | 132±21* | 160±23* | 140±15* | 139±7* | 135±18* |
| Liver (μg/g) | 175±14 | 173±15 | 261±13* | 231±14* | 251±31* | 235±13* | 273±43* | 249±18* | 255±38* | 256±10* |
| Lungs (μg/g) | 59±6 | 59±5 | 72±5* | 69±8* | 82±6* | 76±6* | 78±10* | 76±3* | 84±7* | 77±8* |
| Spleen (μg/g) | 144±17 | 144±17 | 198±13* | 189±11* | 193±20* | 192±22* | 218±17* | 202±25* | 200±22* | 197±26* |
| Ovary/testis (μg/g) | 115±14 | 160±16 | 104±14 | 162±22 | 112±6 | 160±11 | 103±17 | 158±23 | 120±10 | 169±19 |
| Total (μg/g) | 688±65 | 720±72 | 885±51* | 890±77* | 873±99* | 892±78* | 939±19* | 919±98* | 904±92* | 933±90* |
Note:
*
Significantly different from the control group (P<0.05).