Table 2.
Male, female, week 13
| ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sex | Dose (mg/kg) | WBC (103/μL) | RBC (106/μL) | Hb (g/dL) | HCT (%) | MCV (fL) | MCH (Pg) | MCHC (g/dL) | RETI (109 cells/L) | RETI (%) | PLT (103/μL) | PT (sec) | APTT (sec) | |
Male | GI(0) | Mean | 5.28 | 8.25 | 14.3 | 43.4 | 52.6 | 17.3 | 32.9 | 139.9 | 1.69 | 1021 | 11.7 | 19.9 |
SD | 1.83 | 0.30 | 0.4 | 1.2 | 1.4 | 0.6 | 0.6 | 36.1 | 0.43 | 122 | 1.7 | 1.9 | ||
N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
G2 (500) | Mean | 5.13 | 8.23 | 14.4 | 43.6 | 53.1 | 17.5 | 32.9 | 150.6 | 1.83 | 974 | 11.6 | 19.9 | |
SD | 1.40 | 0.34 | 0.4 | 1.0 | 1.9 | 0.8 | 0.5 | 25.0 | 0.28 | 85 | 1.2 | 0.8 | ||
N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
G3 (1,000) | Mean | 4.66 | 8.38 | 14.7 | 44.4 | 53.0 | 17.5 | 33.0 | 145.7 | 1.74 | 977 | 10.3 | 19.6 | |
SD | 1.29 | 0.38 | 0.4 | 1.2 | 1.6 | 0.6 | 0.4 | 18.7 | 0.22 | 110 | 0.9 | 1.5 | ||
N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
G4 (2,000) | Mean | 5.07 | 8.32 | 14.6 | 44.4 | 53.3 | 17.5 | 32.9 | 143.5 | 1.73 | 973 | 11.6 | 20.3 | |
SD | 1.23 | 0.34 | 0.6 | 1.8 | 0.9 | 0.4 | 0.4 | 18.5 | 0.23 | 96 | 2.0 | 1.4 | ||
N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
Female | Gl(0) | Mean | 3.26 | 7.64 | 14.2 | 43.0 | 56.4 | 18.6 | 33.0 | 170.9 | 2.26 | 1171 | 8.5 | 15.6 |
SD | 0.77 | 0.34 | 0.6 | 1.4 | 1.4 | 0.5 | 0.4 | 37.0 | 0.57 | 306 | 0.6 | 0.7 | ||
N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
G2 (500) | Mean | 3.71 | 7.39 | 14.0 | 42.2 | 57.2 | 19.0 | 33.2 | 178.3 | 2.44 | 1204 | 8.3 | 15.9 | |
SD | 1.78 | 0.40 | 0.5 | 1.4 | 2.0 | 0.8 | 0.5 | 71.9 | 1.05 | 172 | 0.3 | 0.9 | ||
N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
G3 (1,000) | Mean | 3.12 | 7.35 | 14.1 | 42.7 | 58.2 | 19.2 | 33.0 | 163.3 | 2.23 | 1139 | 8.3 | 15.3 | |
SD | 1.31 | 0.29 | 0.4 | 1.6 | 3.5 | 0.9 | 0.5 | 27.3 | 0.41 | 115 | 0.5 | 1.0 | ||
N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
G4 (2,000) | Mean | 3.51 | 7.53 | 14.2 | 43.0 | 57.2 | 18.9 | 33.0 | 169.0 | 2.27 | 1122 | 8.7 | 15.1 | |
SD | 1.51 | 0.45 | 0.6 | 1.6 | 2.4 | 0.7 | 0.4 | 46.5 | 0.68 | 108 | 0.7 | 0.7 | ||
N | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
Abbreviations: WBC, white blood cell count; RBC, red blood cell count; Hb, hemoglobin; HCT, hematocrit; MCV, mean cell volume; MCH, mean corpuscular hemoglobin; MCHC, mean cell hemoglobin concentration; RETI, reticulocyte ratio; PLT, platelet count; PT, prothrombin time; APTT, activated partial thromboplastin time; G, group; SD, standard deviation (not significantly different from control); sec, seconds.