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. 2014 Dec 15;9(Suppl 2):109–126. doi: 10.2147/IJN.S57928

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© 2014 Kim et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Histopathological changes in the stomach after treatment with ZnO^AE100(−) at a dose of 500 mg/kg for 90 days. Stomach sections were stained with hematoxylin and eosin. (A) Control for limiting ridge. (C, E and G) Control for mucosa in glandular stomach. (B, D, F and H) 500 mg/kg treatment groups.^a

Notes: ^aArrows in (B) represent squamous cell vacuolation, in (D) show eosinophilic chief cells, in (F) indicate acinar cell apoptosis, and in (H) represent intracytoplasmic hyaline droplets.

Abbreviations: H, squamous cell hyperplasia; N, normal mucosa; NE, normal epithelium; NS, normal submucosa; SI, submucosal edema and inflammatory cell infiltration; ZnO, zinc oxide, ZnO^AE100(−), 100 nm negatively charged ZnO.