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. 2014 Dec 15;9(Suppl 2):109–126. doi: 10.2147/IJN.S57928

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© 2014 Kim et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Histopathological changes in the pancreas after treatment with (A and B) ZnO^AE100(−) and (C and D) ZnO^AE100(+) at a dose of 500 mg/kg for 90 days. The pancreas sections were stained with hematoxylin and eosin. (A and C) Control for acinar cell. (B and D) 500 mg/kg treatment groups.^a

Notes: ^aArrows in (B and D) represent acinar cell apoptosis in the pancreas.

Abbreviations: A, chronic inflammation; DH, ductular hyperplasia; IL, interstitial lymphoid cell infiltration; NA, normal acinar cell; P, prominent acinar cell; ZnO, zinc oxide; ZnO^AE100(−), 100 nm negatively charged ZnO; ZnO^AE100(+), 100 nm positively charged ZnO.