Table 4.
Serum cytokine concentration in mice exposed to SiO2
| Cytokine | NC | SiO2EN20(R) | SiO2EN100(R) | SiO2EN20(−) | SiO2EN100(−) |
|---|---|---|---|---|---|
| IL-1β | 473.54±277.32 | 279.72±130.19 | 255.95±130.19 | 287.81±260.52 | 220.30±118.85 |
| IL-6 | 1.798±1.111 | 1.515±0.408 | 1.265±0.187 | 1.905±2.242 | 1.315±0.358 |
| IL-10 | 41.993±15.239 | 42.192±6.610 | 30.587±8.558 | 38.268±5.874 | 36.087±7.070 |
| IL-12p70 | 13.880±3.625 | 13.148±3.848 | 9.062±2.948* | 6.702±1.997** | 6.713±1.369** |
| IFN-γ | 0.747±0.324 | 0.930±0.241 | 0.692±0.176 | 0.508±0.146 | 0.655±0.167 |
| TNF-α | 122.54±54.341 | 120.60±52.055 | 75.060±23.715 | 102.57±64.786 | 46.717±21.941* |
Notes: Data are presented as the mean ± standard deviation; n=5. Nonparametric Tukey’s multiple comparison test (*P<0.05; **P<0.001 versus NC).
Abbreviations: SiO2, silicon dioxide; NC, normal control; SiO2EN(−), negatively charged silicon dioxide; SiO2EN(R), silicon dioxide modified with L-arginine; IL, interleukin; IFN, interferon; TNF, tumor necrosis factor; n, number.