Table 2.
Toxicity assessmenta (n = 29) | ||||||
---|---|---|---|---|---|---|
Total toxicity (n = 29) | Clofarabine to conditioning (n = 29) |
Conditioning to day + 12 (n = 29) | ||||
Grade 1–2 | Grade 3–4 | Grade 1–2 | Grade 3–4 | Grade 1–2 | Grade 3–4 | |
Renal (creatinine) | 9 (31%) | 1 (3%) | 2 (7%) | 0 | 9 (31%) | 1 (3%) |
Hepatic (total bilirubin) | 14 (48%) | 3 (10%) | 12 (41%) | 2 (7%) | 8 (28%) | 0 |
Hepatic (SGOT) | 14 (48%) | 9 (31%) | 14 (48%) | 7 (24%) | 17 (59%) | 3 (10%) |
Cardiac | 2 (7%) | 0 | 0 | 0 | 2 (7%) | 0 |
Skin | 1 (3%) | 0 | 1 (3%) | 0 | 0 | 0 |
Infection | 0 | 12 (41%)b | 0 | 3 (10%) | 0 | 10 (34%)b |
All toxicities calculated by CTCAE v.3 grading criteria expressed as % of patients experiencing the maximum toxicity level achieved during the indicated time period.
Includes one grade 5 from sepsis on day − 1.