Table 6.
Correlation of expression of metabolism related proteins between primary and metastatic breast cancer according to metastatic site
| Parameters | Total | Bone metastasis | Brain metastasis | Liver metastasis | Lung metastasis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| N = 49 (%) | p-value | n = 13 (%) | p-value | n = 9 (%) | p-value | n = 4 (%) | p-value | n = 23 (%) | p-value | |
| Glut-1 | 0.481 | 0.063 | 1.000 | 1.000 | 0.004 | |||||
| (+) → (+) | 10 (20.4) | 0 (0.0) | 4 (44.4) | 0 (0.0) | 6 (20.4) | |||||
| (+) → (−) | 7 (14.3) | 5 (38.5) | 1 (11.1) | 1 (25.0) | 0 (0.0) | |||||
| (−) → (+) | 11 (22.4) | 0 (0.0) | 2 (22.2) | 0 (0.0) | 9 (39.1) | |||||
| (−) → (−) | 21 (42.9) | 8 (61.5) | 2 (22.2) | 3 (75.0) | 8 (34.8) | |||||
| Hexokinase II | 0.581 | 1.000 | 0.500 | 1.000 | 1.000 | |||||
| (+) → (+) | 11 (22.4) | 1 (7.7) | 1 (11.1) | 0 (0.0) | 9 (39.1) | |||||
| (+) → (−) | 5 (10.2) | 3 (23.1) | 0 (0.0) | 0 (0.0) | 2 (8.7) | |||||
| (−) → (+) | 8 (16.3) | 2 (15.4) | 2 (22.2) | 1 (25.0) | 3 (13.0) | |||||
| (−) → (−) | 25 (51.0) | 7 (53.8) | 6 (66.7) | 3 (75.0) | 9 (39.1) | |||||
| CAIX | 0.688 | N/A | 1.000 | N/A | 1.000 | |||||
| (+) → (+) | 2 (4.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (8.7) | |||||
| (+) → (−) | 2 (4.1) | 0 (0.0) | 1 (11.1) | 0 (0.0) | 1 (4.3) | |||||
| (−) → (+) | 4 (8.2) | 0 (0.0) | 2 (22.2) | 0 (0.0) | 2 (8.7) | |||||
| (−) → (−) | 41 (83.7) | 13 (100.0) | 6 (66.7) | 4 (100.0) | 18 (78.3) | |||||
| MCT4 | 0.002 | 0.250 | 0.250 | 0.500 | 0.004 | |||||
| (+) → (+) | 14 (28.6) | 3 (23.1) | 4 (44.4) | 0 (0.0) | 7 (30.4) | |||||
| (+) → (−) | 2 (4.1) | 0 (0.0) | 0 (0.0) | 2 (50.0) | 0 (0.0) | |||||
| (−) → (+) | 15 (30.6) | 3 (23.1) | 3 (33.3) | 0 (0.0) | 9 (39.1) | |||||
| (−) → (−) | 18 (36.7) | 7 (53.8) | 2 (22.2) | 2 (50.0) | 7 (30.4) | |||||
| GLS1 | 1.000 | 0.063 | 1.000 | 1.000 | 0.289 | |||||
| (+) → (+) | 15 (30.6) | 2 (15.4) | 3 (33.3) | 2 (50.0) | 8 (34.8) | |||||
| (+) → (−) | 8 (16.3) | 0 (0.0) | 1 (11.1) | 1 (25.0) | 6 (26.1) | |||||
| (−) → (+) | 9 (18.4) | 5 (38.5) | 2 (22.2) | 0 (0.0) | 2 (8.7) | |||||
| (−) → (−) | 17 (34.7) | 6 (46.2) | 3 (33.3) | 1 (25.0) | 7 (30.4) | |||||
| GDH | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | |||||
| (+) → (+) | 44 (89.8) | 11 (84.6) | 8 (88.9) | 3 (75.0) | 22 (95.7) | |||||
| (+) → (−) | 2 (4.1) | 1 (7.7) | 1 (11.1) | 0 (0.0) | 0 (0.0) | |||||
| (−) → (+) | 3 (6.1) | 1 (7.7) | 0 (0.0) | 1 (25.0) | 1 (4.3) | |||||
| (−) → (−) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| ASCT2 | 0.092 | 1.000 | 0.219 | 1.000 | 0.375 | |||||
| (+) → (+) | 8 (16.3) | 0 (0.0) | 0 (0.0) | 1 (25.0) | 7 (30.4) | |||||
| (+) → (−) | 10 (20.4) | 1 (7.7) | 5 (55.6) | 0 (0.0) | 4 (17.4) | |||||
| (−) → (+) | 3 (6.1) | 1 (7.7) | 1 (11.1) | 0 (0.0) | 1 (4.3) | |||||
| (−) → (−) | 28 (57.1) | 11 (84.6) | 3 (33.3) | 3 (75.0) | 11 (47.8) | |||||
| ATP synthase | 1.000 | 1.000 | N/A | N/A | N/A | |||||
| (+) → (+) | 48 (98.0) | 12 (92.3) | 9 (100.0) | 4 (100.0) | 23 (100.0) | |||||
| (+) → (−) | 1 (2.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| (−) → (+) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| (−) → (−) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| SDHA | 1.000 | 1.000 | 1.000 | N/A | N/A | |||||
| (+) → (+) | 44 (89.8) | 9 (69.2) | 8 (88.9) | 4 (100.0) | 23 (100.0) | |||||
| (+) → (−) | 2 (4.1) | 2 (15.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| (−) → (+) | 3 (6.1) | 2 (15.4) | 1 (11.1) | 0 (0.0) | 0 (0.0) | |||||
| (−) → (−) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| SDHB | 0.263 | 1.000 | 1.000 | 1.000 | 0.063 | |||||
| (+) → (+) | 24 (49.0) | 4 (30.8) | 3 (33.3) | 1 (25.0) | 16 (69.9) | |||||
| (+) → (−) | 7 (14.3) | 3 (23.1) | 3 (33.3) | 1 (25.0) | 0 (0.0) | |||||
| (−) → (+) | 13 (26.5) | 3 (23.1) | 3 (33.3) | 2 (50.0) | 5 (21.7) | |||||
| (−) → (−) | 5 (10.2) | 3 (23.1) | 0 (0.0) | 0 (0.0) | 2 (8.7) | |||||
| PHGDH | 0.581 | 1.000 | 1.000 | 1.000 | 0.688 | |||||
| (+) → (+) | 22 (44.9) | 3 (23.1) | 6 (66.7) | 1 (25.0) | 12 (52.2) | |||||
| (+) → (−) | 5 (10.2) | 2 (15.4) | 1 (11.1) | 0 (0.0) | 2 (8.7) | |||||
| (−) → (+) | 8 (16.3) | 2 (15.4) | 1 (11.1) | 1 (25.0) | 4 (17.4) | |||||
| (−) → (−) | 14 (28.6) | 6 (46.2) | 1 (11.1) | 2 (50.0) | 5 (21.7) | |||||
| PSPH | 1.000 | N/A | 1.000 | 1.000 | 1.000 | |||||
| (+) → (+) | 1 (2.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (4.3) | |||||
| (+) → (−) | 3 (6.1) | 0 (0.0) | 1 (11.1) | 0 (0.0) | 2 (8.7) | |||||
| (−) → (+) | 2 (4.1) | 0 (0.0) | 0 (0.0) | 1 (25.0) | 1 (4.3) | |||||
| (−) → (−) | 43 (87.8) | 13 (100.0) | 8 (88.9) | 3 (75.0) | 19 (82.6) | |||||
| PSAT1 | 0.607 | 1.000 | 1.000 | 1.000 | 0.219 | |||||
| (+) → (+) | 1 (2.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (4.3) | |||||
| (+) → (−) | 9 (18.4) | 3 (23.1) | 0 (0.0) | 1 (25.0) | 5 (21.7) | |||||
| (−) → (+) | 6 (12.2) | 2 (15.4) | 1 (11.1) | 2 (50.0) | 1 (4.3) | |||||
| (−) → (−) | 33 (67.3) | 8 (61.5) | 8 (88.9) | 1 (25.0) | 16 (69.6) | |||||
| SHMT1 | 1.000 | 1.000 | 1.000 | N/A | 1.000 | |||||
| (+) → (+) | 10 (20.4) | 0 (0.0) | 2 (22.2) | 0 (0.0) | 8 (34.8) | |||||
| (+) → (−) | 2 (4.1) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 1 (4.3) | |||||
| (−) → (+) | 1 (2.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (4.3) | |||||
| (−) → (−) | 36 (73.5) | 12 (92.3) | 7 (77.8) | 4 (100.0) | 13 (56.5) | |||||
| GLDC | 0.143 | 0.375 | 1.000 | 1.000 | 0.508 | |||||
| (+) → (+) | 12 (24.5) | 0 (0.0) | 3 (33.3) | 1 (25.0) | 8 (34.8) | |||||
| (+) → (−) | 5 (10.2) | 1 (7.7) | 1 (11.1) | 0 (0.0) | 3 (13.0) | |||||
| (−) → (+) | 12 (24.5) | 4 (30.8) | 1 (11.1) | 1 (25.0) | 6 (26.1) | |||||
| (−) → (−) | 20 (40.8) | 8 (61.5) | 4 (44.4) | 2 (50.0) | 6 (26.1) | |||||
*p-value was calculated by McNemar test.
Bold represents p < 0.05.