FIG. 3.

Hiveplots showing additional phenotypic relationships of genes associated by level of evidence 1 with intellectual disability (A), microcephaly (B), molar tooth malformation (C), and retinal dystrophy (D). Red node in all panels indicates primary phenotype. Blue nodes indicate associated genes. Copper nodes represent secondary associated phenotypes. Green edges represent Level 1 associations between genes and the primary phenotype. Pink edges represent other associations (of any level of evidence) between those genes and the secondary phenotypes. Genes for intellectual disability and microcephaly are more likely to have secondary phenotypic associations, and genes for retinal dysplasia are less likely to have secondary phenotypic associations.