Table 1. Baseline Risk in patients with no prior CVD at baseline.

	Estrogen Alone							Estrogen + Progestin							Combined Trial
		Controls			Cases				Controls			Cases				Controls			Cases
	N	Mean	SD	N	Mean	SD	p-value	N	Mean	SD	N	Mean	SD	p-value	N	Mean	SD	N	Mean	SD	p-value
Age at screening	273	66.29	6.44	112	66.92	6.58	0.386	422	66.59	6.86	157	65.76	7.31	0.200	695	66.47	6.69	269	66.24	7.02	0.632
Body-mass index (kg/m²), baseline	273	29.18	5.44	112	30.17	6.10	0.118	419	27.73	5.79	157	28.64	5.96	0.097	692	28.30	5.70	269	29.28	6.05	0.020
Hip circumference (cm), baseline	273	109.79	12.58	112	109.79	13.00	0.997	420	105.44	11.38	157	108.06	13.55	0.020	693	107.15	12.05	269	108.78	13.33	0.069
Waist circumference (cm), baseline	273	90.60	13.03	112	94.61	14.80	0.009	420	86.18	13.42	157	90.30	14.39	0.001	693	87.92	13.43	269	92.09	14.69	<.001
Waist/hip ratio, baseline	273	0.83	0.09	112	0.86	0.08	<0.005	420	0.82	0.07	157	0.83	0.07	0.006	693	0.82	0.08	269	0.85	0.08	<.001
Weight (kg), baseline	273	76.28	15.09	112	78.23	17.41	0.272	421	72.02	16.01	157	74.64	16.68	0.084	694	73.69	15.78	269	76.13	17.05	0.036
Diastolic BP (mm Hg), baseline	272	76.13	8.98	112	77.80	9.73	0.108	422	74.80	9.31	157	76.81	10.60	0.0271	694	75.32	9.20	269	77.22	10.24	0.006
Systolic BP (mm Hg), baseline	273	130.19	16.91	112	140.21	18.05	<0.001	422	129.04	17.53	157	133.86	19.18	0.004	695	129.49	17.28	269	136.50	18.94	<.001
BL Glucose, mg/dL	270	105.06	27.99	112	119.74	50.05	<0.003	422	102.55	25.80	155	115.31	49.38	<.001	692	103.53	26.68	267	117.17	49.62	<.001
BL HDL-C, mg/dL (MRL)	272	54.08	14.16	110	49.59	13.11	0.004	421	55.72	14.77	155	50.36	13.45	<.001	693	55.07	14.55	265	50.04	13.29	<.001
BL Triglyceride, mg/dL (MRL)	273	161.84	86.36	112	174.21	91.83	0.212	422	148.15	77.41	156	182.13 109.70		<.001	695	153.53	81.26	268	178.82	102.50	<.001
BL LDL-C, mg/dl	266	143.45	33.58	105	153.38	34.15	0.011	416	141.43	33.41	148	154.22	32.70	<.001	682	142.22	33.47	253	153.87	33.25	<.001
BL Total Cholesterol, mg/dL	273	229.30	37.44	112	236.58	39.19	0.088	422	226.69	36.38	156	239.63	37.26	<.002	695	227.72	36.80	268	238.36	38.04	<.001
BL C-reactive protein, ug/ml	264	3.85	4.38	108	4.99	4.60	0.025	409	3.27	4.63	153	4.20	4.65	.034	673	3.50	4.54	261	4.53	4.64	0.002

		Estrogen Alone					Estrogen + Pro					Combined Trial
		Controls		Cases			Controls		Cases			Controls		Cases
		N	%	N	%	p-value	N	%	N	%	p-value	N	%	N	%	p-value
Race/ethnicity	White	211	77.29	85	75.89	0.787	371	87.91	140	89.17	0.899	582	83.74	225	83.64	0.799
	Black	42	15.38	16	14.29		23	5.45	7	4.46		65	9.35	23	8.55
	Hispanic	13	4.76	6	5.36		17	4.03	5	3.18		30	4.32	11	4.09
	Other	7	2.56	5	4.46		11	2.61	5	3.18		18	2.59	10	3.72
Education	Up to high school diploma/GED	91	33.58	53	48.62	0.014	108	25.71	56	35.90	0.055	199	28.80	109	41.13	0.001
	School after high school	111	40.96	39	35.78		166	39.52	54	34.62		277	40.09	93	35.09
	College degree or higher	69	25.46	17	15.60		146	34.76	46	29.49		215	31.11	63	23.77
Smoking status	Never	145	54.92	54	49.54	<.0003	233	55.88	71	46.71	<.001	378	55.51	125	47.89	<.001
	Past	98	37.12	30	27.52		152	36.45	49	32.24		250	36.71	79	30.27
	Current	21	7.95	25	22.94		32	7.67	32	21.05		53	7.78	57	21.84
Treated diabetes (pills or shots)	No	259	94.87	90	80.36	<.001	404	95.73	140	89.74	0.007	663	95.40	230	85.82	<.001
	Yes	14	5.13	22	19.64		18	4.27	16	10.26		32	4.60	38	14.18
Hypertension	0	124	49.40	37	35.92	0.021	225	59.21	60	43.48	0.002	349	55.31	97	40.25	<.001
	1	127	50.60	66	64.08		155	40.79	78	56.52		282	44.69	144	59.75
Anti-hyperlipidemic medication use	No	252	92.31	101	90.18	0.492	392	92.89	143	91.08	0.465	644	92.66	244	90.71	0.312
	Yes	21	7.69	11	9.82		30	7.11	14	8.92		51	7.34	25	9.29
HRT use status	Never used	154	56.41	69	61.61	0.410	316	74.88	116	73.89	0.352	470	67.63	185	68.77	0.233
	Past user	88	32.23	35	31.25		79	18.72	35	22.29		167	24.03	70	26.02
	Current user	31	11.36	8	7.14		27	6.40	6	3.82		58	8.35	14	5.20
Family history of premature MI (<55 male, <65 female)	No	196	82.01	66	70.97	0.027	309	83.51	97	75.78	0.052	505	82.92	163	73.76	0.003
	Yes	43	17.99	27	29.03		61	16.49	31	24.22		104	17.08	58	26.24