Table 2.

Biochemistry/hematology data by dose cohort

Measure	Melatonin dose (mg)
	20	30	50	100
Hemoglobin g/L
Baseline	147 [139–161]	138 [127–142]	149 [142–169]	147 [145–148]
6 hr	145 [136–153]	133 [128–148]	145 [145–166]	141 [139–147]
Leukocytesa 109/L
Baseline	5.0 [3.7–6.9]	5.6 [4.3–8.7]	4.9 [4.2–5.7]	5.3 [5.3–6.7]
6 hr	5.0 [4.2–6.7]	5.3 [4.2–6.6]	5.7 [4.3–6.7]	5.6 [4.2–6.4]
AST Units/L
Baseline	33 [24–34]	25 [18–30]	24 [20–51]	23 [17–41]
6 hr	24 [17–25]	21 [16–29]	22 [17–33]	23 [16–36]
Bilirubin μmol/L
Baseline	17 [14–29]	16 [9–38]	18 [7–23]	11 [9–14]
6 hr	15 [12–29]	17 [8–35]	19 [9–23]	14 [9–17]
Creatinine μmol/L
Baseline	83 [74–86]	73 [70–96]	71 [68–77]	80 [62–85]
6 hr	73 [71–83]	68 [60–92]	66 [63–73]	79 [56–84]
Glucoseb mmol/L
Baseline	5.0 [4.3–5.3]	4.5 [3.7–5.6]	4.1 [3.6–4.7]	4.4 [3.9–5.0]
6 hr	4.4 [3.8–5.1]	4.4 [4.4–5.4]	4.0 [3.7–5.3]	4.2 [3.9–5.8]
Potassiumc mmol/L
Baseline	4.0 [3.9–4.6]	3.9 [3.5–4.2]	3.7 [3.6–3.8]	4.0 [3.6–4.0]
6 hr	3.8 [3.7–3.9]	3.9 [3.4–4.3]	3.8 [3.7–3.9]	3.8 [3.7–4.0]
Sodiumd mmol/L
Baseline	140 [140–141]	140 [138–140]	142 [140–143]	141 [140–143]
6 hr	141 [139–142]	140 [139–142]	141 [139–142]	141 [140–141]

Median [range], n = 5 per dose cohort.

^aBaseline >6 hr (P < 0.001) across all subjects, no effect of dose.

^bBaseline >6 hr (P = 0.013) across all subjects, no effect of dose.

^cBaseline >6 hr (P < 0.001) across all subjects, no effect of dose.

^dBaseline >6 hr (P = 0.001) across all subjects, no effect of dose.