Table 3.

Sleep scale domain total scores by dose cohort

Dose	Timing of sleep scale	Disturbance domain	Efficiency domain	Supplementation domain
20 mg	Before study visit	59 [16–423]	397 [310–461]	2 [2–109]
	Study visit	46 [8–145]	443 [324–490]	22 [0–94]
	Week after	99 [5–200]	429 [400–468]	2 [0–11]
30 mg	Before study visit	72 [36–180]	376 [313–420]	16 [7–79]
	Study visit	37 [29–142]	409 [272–487]	59 [4–139]
	Week after	81 [25–263]	313 [272–412]	36 [21–87]
50 mg	Before study visit	59 [11–104]	436 [268–456]	7 [0–160]
	Study visit	77 [13–234]	413 [312–458]	13 [2–35]
	Week after	60 [13–168]	399 [369–430]	1 [0–135]
100 mg	Before study visit	65 [61–464]	329 [317–453]	9 [0–154]
	Study visit	21 [10–205]	449 [251–458]	82 [49–137]
	Week after	95 [71–190]	379 [319–469]	18 [13–108]

Median [range], n = 5 per dose cohort.

No significant changes between time points or dose cohorts.