Table 4.
Melatonin pharmacokinetic data in individual subjects
| Dose and subject ID no. | AUCa ng/ml/min | Half-life mins | Cmaxb ng/ml | Tmax min |
|---|---|---|---|---|
| 20 mg | ||||
| 1 | 1102 | 62.01 | 12.80 | 30.00 |
| 2 | 3266 | 52.62 | 35.70 | 60.00 |
| 3 | 3405 | 58.76 | 30.33 | 60.00 |
| 4 | 1564 | 50.38 | 20.86 | 30.00 |
| 5 | 13616 | 52.07 | 147.68 | 30.00 |
| 30 mg | ||||
| 6 | 2491 | 48.33 | 30.09 | 30.00 |
| 7 | 1866 | 48.14 | 33.67 | 30.00 |
| 8 | 1304 | 71.62 | 12.95 | 30.00 |
| 9 | 822 | 63.22 | 6.25 | 60.00 |
| 10 | 1640 | 62.96 | 8.51 | 120.00 |
| 50 mg | ||||
| 11 | 6034 | 55.58 | 75.42 | 30.00 |
| 12 | 1812 | 45.06 | 24.53 | 30.00 |
| 13 | 8915 | 51.39 | 113.78 | 30.00 |
| 14 | 4234 | 41.75 | 67.84 | 30.00 |
| 15 | 6554 | 53.09 | 91.38 | 30.00 |
| 100 mg | ||||
| 16 | 9570 | 44.41 | 103.22 | 60.00 |
| 17 | 5639 | 29.47 | 94.00 | 60.00 |
| 18 | 18229 | 47.32 | 220.26 | 30.00 |
| 19 | 4458 | 45.18 | 47.71 | 60.00 |
| 20 | 11062 | 55.89 | 138.83 | 30.00 |
AUC, area under the concentration curve.
Significant effect of dose (P = 0.006).
Significant effect of dose (P = 0.006).