Table 5.

Urine 6-hydroxymelatonin in individual subjects

Dose and subject ID no.	Total 6-hydroxymelatonin excreted in 6 hra mg	Median dose cohort total 6-hydroxymelatonin excreted in 6 hr mg
20 mg
1	2.22	3.72
2	4.38
3	3.72
4	6.20
5	2.96
30 mg
6	3.81	5.08
7	4.60
8	8.80
9	5.55
10	5.08
50 mg
11	34.98	13.95
12	28.45
13	13.95
14	11.23
15	5.82
100 mg
16	22.92	37.09
17	37.09
18	47.09
19	34.54
20	66.03

^aSignificant effect of dose (P = 0.0018).