Table 1.

RNA binding domains and representative proteins with functions in development, differentiation, and reprogramming

RNA binding domain	Example	Function	Reference
RRM	Rbfox2	Regulation of alternative splicing of reprogramming and differentiation	Yeo et al., 2009; Venables et al., 2013b
SR	Son	Regulation of alternative splicing of pluripotency genes in hESC	Lu et al; 2013
KH	hnRNP K and hnRNP E1/E2	Translational control in erythroid differentiation	Ostareck et al., 1997
RGG	hnRNPU	RNA/DNA binding, activation of OCT4 gene expression	Choi et al., 2011
PAZ	Ago2	Regulation of miRNA and siRNA pathways for proper ESC maintenance	Shekar et al., 2011
dsRBD	Drosha	microRNA maturation	Kanellopoulou et al., 2005; Wang et al., 2007; Doyle et al., 2013
DEAD box	DDX5	Regulation of splicing and transcription in cell differentiation and proliferation	Caretti et al., 2006
ZnF	Lin28	Inhibition of pri-miR-let7 processing	Piskounova et al., 2011
PuF	Pum1	Transcriptional repression and activation by binding to 3′UTR of target mRNA	Galgano et al., 2008
Non canonical	Ezh2	Chromatin silencing through H3 K27 trimetylation	Zhao et al., 2010