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. Author manuscript; available in PMC: 2014 Dec 30.
Published in final edited form as: Front Biol (Beijing). 2014 Oct;9(5):382–388. doi: 10.1007/s11515-014-1325-z

Figure 1.

Figure 1

Role of PACT/RAX in the development and diseases. PACT/RAX is activated by various cellular stresses and interacts with PKR, resulting in eIF2α phosphorylation and subsequent inhibition of protein synthesis and induction of apoptosis or growth inhibition. RAX/PACT-PKR interaction promotes p53 sumoylation, leading to G1 cell cycle arrest. PACT/RAX associates with TRBP, Dicer and Ago2 and regulates siRNA/miRNA generation and gene silencing. PACT/RAX knockout or mutation leads to diseases and serious development defects through unknown mechanisms. PACT/RAX is an important stress responsive protein and plays important in cell physiology and development.