Table 2.
DbTF – target gene categorisation
| Novel DbTF | Function | CCK2RDbTF | TGs | AR42J expressed | Gastrin responsive |
|---|---|---|---|---|---|
| CREM | Activator | CREB1 | JUN | Yes | Yes |
| FOXP3 | Repressor | CREB1 | IFNG | No | No |
| Repressor | CREB1 | IL10 | No | No | |
| Repressor | CREB1 | BCL2 | No | No | |
| Repressor | CREB1 | MALAT1 | No | No | |
| TCF7L2 | Repressor | CREB1 | MYOD1 | No | No |
| FOXP3 | Repressor | NFkB1 | PIGR | No | No |
| Repressor | NFkB1 | CXCL5 | No | No | |
| Repressor | NFkB1 | VCAM1 | No | No | |
| Repressor | NFkB1 | VWF | No | No | |
| Repressor | NFkB1 | IFNG | No | No | |
| Repressor | NFkB1 | IL8 | No | No | |
| Repressor | NFkB1 | BCL2A1 | No | No | |
| Repressor | NFkB1 | NFKB1 | Yes | Yes | |
| Repressor | NFkB1 | IER3 | Yes | Yes | |
| Repressor | NFkB1 | CD40LG | No | No | |
| Repressor | NFkB1 | SELE | No | No | |
| Repressor | NFkB1 | ALOX5AP | Yes | Yes | |
| SMAD3 | Repressor | NFkB1 | MMP9 | No | No |
| PARP1 | Activator | NFkB1 | BRCA2 | Yes | Yes |
The table lists shared target genes of the novel DbTFs and CCK2R core DbTFs, retrieved through use case I-III. Key for columns (left to right): Novel DbTFs: Proteins that transcriptionally regulate the core CCK2R-DbTFs (CREB1, NFkB1 and TCF7L2); Function: Role of the regulators; CCK2R-DbTF: core CCK2R-DbTF that is regulated by the Novel DbTF indicated in column one; TGs: Target genes retrieved from GeXKB that are found to be common between the novel DbTFs and the CCK2R core DbTF(s); AR42J expressed: known status of target genes expression in AR42J cells [19]; Gastrin responsive: known responsiveness of target genes to gastrin treatment [19].