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. 2014 Dec 21;20:2746–2752. doi: 10.12659/MSM.892597

Figure 2.

Figure 2

NF-κB activation contributes to the regulation of CXCR4 in neuroblastoma cells (A1, A2, A3), (B1, B2, B3). Cells were treated with TNF-α (20 ng/ml) or NF-κB inhibitor PDTC (50 μM) for 24 h. NF-κB(p65) and CXCR4 expression were analyzed by Western blot analysis. NF-κB (p65) and CXCR4 protein expression were upregulated in SK-N-BE(2) or SH-SY5Y cells after being pre-treated with TNF-α and were downregulated when pre-treated with PDTC. β-actin was used as the loading control. * P<0.05 vs. untreated group. Data are expressed as mean ±SD.