Skip to main content
. Author manuscript; available in PMC: 2014 Dec 30.
Published in final edited form as: Handb Clin Neurol. 2014;125:89–111. doi: 10.1016/B978-0-444-62619-6.00006-9

Fig. 6.2.

Fig. 6.2

Epigenetic modifications associated with alcoholism. CREB-binding protein (CBP) and histone deacetylase (HDAC) activity are altered by acute alcohol exposure. Chronic alcohol exposure results in neuroadaptations opposing the acute effects of alcohol in order to maintain a homeostatic state. Withdrawal after chronic alcohol exposure is associated with increased HDAC activity and decreased levels of CBP and the associated histone acetylation (Starkman et al., 2012). DNMT, DNA methyltransferase; Ac, acetyl; Me, methyl; HAT, histone acetylase.