Figure 3.
The neurogenic effect of wheel running. A) Numbers of BrdU+ neurons plotted against average distance traveled in km/day across all the runners in the study. Each strain is shown separately along with linear trend lines. Analysis of covariance revealed significantly different linear trends depending on strain. B) Average neurogenic effect of wheel running (numbers of BrdU+ neurons/km) shown separately for each strain. The neurogenic effect of running was defined for each runner in the study as follows: total number of BrdU+ neurons observed in the runner minus average number in the sedentary group from the same strain divided by the total distance that runner traveled over the course of the study. No significant strain differences in the neurogenic effect of running were observed. Standard error bars shown, n=5–7 animals per group.