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. 2014 Dec 30;9(12):e115875. doi: 10.1371/journal.pone.0115875

Figure 9. A multi-year treatment cycle with 70% population coverage and drug efficacy of 90%.

Figure 9

Panels indicate results for (a) a simple Macdonald MWB model without mating; (b) a MWB model with NB distribution and an included mating function (equation (36), S3 Appendix in S1 Text) having breakpoint level Inline graphic (shaded range, lower left hand panel). On both left hand plots, solid black is the overall community MWB, Inline graphic; gray is the untreated group Inline graphic, and the dashed line is the treated group Inline graphic. The upper right hand panel indicates yearly snail prevalence of infection without (solid line) or with (dashed line) inclusion of the mating factor, and hence the breakpoint, in the model. The lower right hand panel indicates expected human prevalence with MDA treatment in the breakpoint setting.