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. 2014 Dec 30;9(12):e116221. doi: 10.1371/journal.pone.0116221

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© 2014 Karpievitch et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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SVD trends in raw (left panel) and normalized (right panel) clinical study data. Percentage at the top of each subplot shows the percent of the variation in the data explained by each trend. On the x-axis is sample index from 1 to 79, where each circle represents a sample. Samples are grouped by disease group with 39 control samples numbered 1–39 followed by 40 diabetes samples numbered 40–79. Samples are in chronological run order on the instrument within each group. Values on the y-axis satisfy equation: R = UDV’ where R is a matrix of residuals (left panel) and matrix of normalized intensities (right panel); columns of V represent trends observed in the data. Three trends that explain the most amount of variation are plotted for raw and normalized data.