Table 2.
ETN attenuated MCA remodeling in SHRSP
| SHRSP + PBS | SHRSP + ETN | WKY Rats (36) | |
|---|---|---|---|
| n | 7 | 8 | 4 |
| Diameter, μm | |||
| Lumen | 225 ± 6 | 253 ± 5* | 286 ± 8 |
| Outer | 278 ± 9 | 293 ± 5 | 314 ± 11 |
| Wall thickness, μm | 26 ± 1 | 20 ± 1* | 14 ± 1 |
| Wall-to-lumen ratio | 0.113 ± 0.01 | 0.079 ± 0.01* | 0.05 ± 0.004 |
| CSA, μm2 | |||
| Lumen | 40,086 ± 2,175 | 50,374 ± 2,062* | 64,398 ± 3,556 |
| Vessel | 60,422 ± 3,771 | 67,351 ± 2,426 | 77,452 ± 5,011 |
| Wall | 20,337 ± 1,683 | 16,976 ± 857* | 13,054 ± 1,607 |
| Distensibility | 41 ± 11 | 40 ± 3 | 45 ± 3 |
| Vessel stress, dynes/cm2 | 356 ± 11 | 520 ± 31* | 854 ± 74 |
| β-Coefficient | 7.12 ± 0.7 | 7.91 ± 0.7 | 8.61 ± 0.6 |
| Myogenic tone, % | 28 ± 7 | 33 ± 2 | NA |
Values are means ± SE at an intraluminal pressure of 80 mmHg. NA, nonapplicable; CSA, cross-sectional area; WKY, Wistar Kyoto.
*
Significantly different from SHRSP + PBS (P < 0.05). The WKY values contained in this table have been previously published (36); they are included here to provide an indication of the extent of the remodeling in SHRSP.