FIGURE 3.

Androgens are required for enhancement of regeneration by exercise or ES

A: average (+95% confidence limits) fold changes in median lengths of profiles of regenerating axons 2 wk after the common fibular nerve was cut and repaired are shown for male and female mice. Animals were exercised using either slow continuous walking for 1 h or a more intense interval training strategy. Some animals were treated with a sustained release dosage form of the androgen receptor blocker flutamide, with either sex-appropriate exercise or no exercise. Animals in one group of male mice were castrated at the time of nerve repair. Data from Refs. 72, 81. B: similar flutamide treatment blocked the enhancing effect of a single application of ES in both male and female mice. Data are from Ref. 75.