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. 2014 Nov;29(6):403–412. doi: 10.1152/physiol.00008.2014

FIGURE 3.

FIGURE 3.

Experimental validation in a model system of candidate genes for human high-altitude adaptation

Downregulation of human SENP1 and ANP32D orthologs in Drosophila enhances survival under hypoxia. The da-Gal4 driver was used to ubiquitously knock down the individual candidate genes by crossing with respective UAS-RNAi lines. Eclosion rates were then measured at 21% and 5% O2. A: significant increase in eclosion rate under 5% O2 in three RNAi lines targeting the same human SENP1 ortholog (CG32110). B: the differences in eclosion rates were also significant in the two lines targeting the human ANP32D ortholog (Mapmodulin). Each bar represents mean 5 SE of eclosion rate. The w1118 and da-Gal4 stocks were tested and used as background controls. Figure adapted from Zhou et al. (51), with permission from Elsevier.