Table 3. Multivariate Cox proportional hazards regression of survival in the validation cohorts.

Cohort	Factors	Hazard ratio	95% Confidence interval	P-value
JP	17-gene + vs. −	2.35	(1.33, 4.16)	3.4×10−3
	Age (per year)	1.04	(1.01, 1.08)	2.4×10−2
	Gender male vs. female	0.79	(0.41, 1.54)	4.9×10−1
	Smoking + vs. −	1.34	(0.70, 2.58)	3.7×10−1
	Stage	2.59	(1.52, 4.41)	4.4×10−4
	Gene alteration + vs. −	0.51	(0.30, 0.86)	1.2×10−2
	Myc level high vs. low	0.81	(0.31, 2.11)	6.7×10−1
SE	17-gene + vs. −	2.03	(1.09, 3.76)	2.5×10−2
	Age (per year)	1.00	(0.96, 1.03)	8.3×10−1
	Gender male vs. female	0.91	(0.50, 1.64)	7.5×10−1
	Stage	1.50	(0.70, 3.23)	3.0×10−1