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. 2014 Dec 30;9(12):e115937. doi: 10.1371/journal.pone.0115937

Figure 1. Forsythin is an inhibitor of PDE4.

Figure 1

A–C. The chemical structure of Forsythin extracted from Forsythia suspensa seeds. Forsythin is an o-linked β-D-glucopyranosylated lignin that can be hydrolyzed (Red line). D. Predicted docking site of Forsythin with PDE4. E. Predicted residue electrostatic and van der Waals interactions between PDE4 amino acids and Forsythin. Using ZINCPharmer [24], a pharmacophore model was generated (upper left) and used to screen the lead compounds from an 18.3 million purchasable compound library.