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. 2014 Dec 30;9(12):e116204. doi: 10.1371/journal.pone.0116204

Figure 6. Serial MRI studies after MRI-monitored injection of iron-oxide labeled C.novyi-NT into a solid Panc02 tumor.

Figure 6

Axial T2*-weighted acquired before (a), immediately after percutaneous injection (b), and 7-days after injection of iron-labeled C.novyi-NT (c) (areas within these dashed lines indicate tumor region). Hematoxylin-eosin (HE) staining (d), Gram staining (e) and Prussian blue staining (f) histology slide depicted zones of viable tumor and necrosis, C.novyi-NT anaerobes within necrotic areas, and corresponding presence of iron-oxide probe labels within these same zones. Size bar for MRI image a, b and c = 2 mm. Scale bars within d, e and f = 50 µm.