Fig. 1.

Percentage of Src homology 2 domain-containing tyrosine phosphatase-2(SHP-2), phospoho-extracellular signal-regulated kinase-1 (p-ERK1), p-ERK2, and protein tyrosine phosphatase-1B (PTP1B) expression in the mediobasal hypothalamus 2 h after the last injection in animals injected once a day with 6 doses of saline (6 Saline), single dose of LPS (100 μg/kg ip; 5-Saline + 1 LPS), or repeated doses of LPS (6 LPS). One-way ANOVA followed by Newman Keuls post hoc test was performed. Data are expressed as means ± SE (n = 6–7). *P < 0.05.