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Cumulative food intake 2 h (A) and 14 h (B) after the last injection and body weight gain 14 h after the last injection (C) in animals injected once a day with 6 doses of saline (6 Saline), single dose of LPS (100 μg/kg ip; 5 Saline + 1 LPS), or repeated doses of LPS (6 LPS), followed by icv injection of vehicle or PTP1B inhibitor (3 nmol/rat, 5 μl). Two-way ANOVA followed by Newman-Keuls post hoc test was performed. Data are expressed as means ± SE (n = 10–11). *P < 0.05.
