Table 3. Significant networks represented by top GWAS hits.

Genes from GWAS analysis with adjustment for the first four components
ID	Molecules inNetwork	Score	FocusMolecules	Top Diseasesand Functions	P-value
1	ARCN1,ARID4A,ARL17A,C12orf29,C1orf50,CARM1,CCDC141,CUEDC1,EIF4A3,ELMSAN1,EVC,EYA2,FERMT1,GLI1,GRTP1,HNF1A,IFT46,LDLRAD4,LIPA,MAGEA9/MAGEA9B,PIEZO2,POTEJ,SDK2,SFXN2,SLC16A13,SLC22A12,TBC1D8B,TNF,tretinoin,UBC,USP35,USP40,USP42,ZBTB40,ZNF442	43	18	Cell Cycle,Cellular Growthand Proliferation,Gene Expression	2.12E-19
2	ACSL1,Akt,ANGPTL4,ARAP3,ARHGAP26,Cyp2j9,Focal adhesion kinase,ganglioside GD2,GLIS3,GYS2,IL22R1-IL10R2,Immunoglobulin,INSRR,Insulin,IPO8,LPP,miR-491–5p (and other miRNAs w/seed GUGGGGA),NCOA7,NFkB (complex),NRG4,NTN4,P38 MAPK,PID1,PKN3,PTPRB,RAB31,RGS5,SCNN1A,SLC2A5,SLC30A7,SLC35B2,SLC3A1,TNFRSF1A,TRAF1-TRAF2-TRAF3,WISP3	28	13	Endocrine SystemDevelopment andFunction, TissueMorphology,Cellular Development	6.91E-13
3	ADAMDEC1,ADAMTS3,AKT2,ART3,ATP10A,beta-estradiol,Ca2+,Calmodulin-Camk4a2+,CCDC82,Cetn4,COA4,CPA2,CTNNA2,DGKB,DOK6,ERBB2,FURIN,GDPD3,HDAC4,HNF4A,Interferon alpha,INTS4,KCNIP1,MAPK1,MITF,NUDT6,PDE11A,PRR15L,RHOBTB2,SLC24A3,SPAG16,Timd2,TMEM258,TRPM1,ZNRF3	28	13	Energy Production,Molecular Transport,Nucleic AcidMetabolism	6.91E-13
4	SYT14,SYT16	3	1	Hereditary Disorder,NeurologicalDisease, Cancer	4.98E-02
5	KIAA1524,SLC12A8	3	1	Cancer, CellularMovement,GastrointestinalDisease	4.98E-02

The networks were generated using Ingenuity Pathways Analysis (Ingenuity Systems, www.ingenuity.com). Each gene identifier was mapped to its corresponding gene object in the Ingenuity Pathways Knowledge Base (IPKB) and overlaid onto a global molecular network developed from information contained in the IPKB. Scores, corresponding to degree of enrichment, are negative log of p-values from Fisher’s exact test. Genes in bold (focus molecules) are genes that correspond to top hit SNPs in our genome-wide association study of placental abruption.