Table 7. Association between risk of placental abruption and weighted genetic risk score (WGRS) computed from SNPs selected in multivariable analyses using repeated 10-fold cross-validations.
Weighted Genetic Risk Score (GRS) | |||||
1st Quartile | 2nd Quartile | 3rd Quartile | 4th Quartile | p-value | |
Genome-wide Association Analysis* | |||||
OR ** | 1 | 2.53 | 3.78 | 8.40 | <0.001 |
(95% CI) | (Ref.) | (1.47–4.71) | (2.2–6.4) | (5.8–12.56) |
*Cross-validated WGRS computed from SNPs selected from multivariable analyses.
**Cross-validated odds ratios (and 95% confidence intervals) from logistic regression models adjusted for sex, and population admixture, p-values associated to chi-square global test.