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. Author manuscript; available in PMC: 2014 Dec 30.
Published in final edited form as: Curr Biol. 2010 Sep 14;20(17):R754–R763. doi: 10.1016/j.cub.2010.06.070

Figure 1. Activator synergy.

Figure 1

Several nonexclusive mechanisms can be envisioned by which two transcriptional activators augment each other’s function. (A) Activators A and B cooperatively bind to linked sites. (B) A and B coordinately bind a third protein, X, which stabilizes the binding of A and B. (C) A recruits a histone remodeling protein that facilitates the binding of B. (D) A leads to ‘slippage’ of the nucleosome and thereby uncovers the B binding site. Reproduced with permission from [125].

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