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(A) The T1 enhancer bypasses the ftz locus to activate Scr within the Antennapedia gene complex of Drosophila. Reproduced with permission from [58]. (B) The primary enhancer controlling Shh expression in the developing vertebrate limb bud is located within the intron of the Lmbr1 locus (unfilled box), which maps nearly one megabase from the Shh transcription start site. Reproduced with permission from [63].
