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. Author manuscript; available in PMC: 2014 Dec 30.
Published in final edited form as: Curr Biol. 2010 Sep 14;20(17):R754–R763. doi: 10.1016/j.cub.2010.06.070

Figure 4. Overlapping activators define the organizer.

Figure 4

(A) Xenopus blastula. Xnrs (Xenopus Nodal-related signaling molecules) and pSmads are expressed in vegetal regions of the embryo. The homeobox gene Siamois is selectively expressed along the presumptive dorsal surface of the embryo. The two activators, pSmads and Siamois, are co-expressed in the region of the presumptive organizer where they activate the expression of the Goosecoid (Gsc) gene. (B) Summary of Gsc regulation in the organizer. The Smads and Siamois interact with Gsc regulatory sequences and activate expression. Reproduced with permission from [125].

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