Table 3. Dosing error with pharmacogenomic algorithms based on rs12777823 genotype.

	rs12777823 genotype
	GG (n=157)	GA (n=97)	AA (n=20)	p value*
Dose (mg/day)
Observed	6.8 (5.0 to 8.6)	5.7 (4.3 to 7.5)	5.2 (4.3 to 7.3)	0.0047
IWPC	6.0 (5.1 to 6.9)†	6.0 (5.3 to 7.0)	6.3 (4.9 to 6.8)	0.5803
WD	7.0 (5.9 to 8.3)	7.2 (6.3 to 8.6)‡	7.7 (6.2 to 8.5)§	0.1665
Prediction error (mg/day)
IWPC	−0.8 (−2.3 to 0.4)	0.1 (−1.2 to 1.6)	0.7 (−0.4 to 1.5 )	<0.0001
WD	0.3 (−1.4 to 1.4)	1.2 (0.02 to 2.6)	2.0 (0.6 to 2.8)	<0.0001

Median (IQR)

^*Comparison between genotype groups

^†p<0.001 for IWPC predicted versus observed dose with the GG genotype

^‡p<0.001 for WD predicted versus observed dose with the GA genotype

^§p=0.0036 for WD predicted versus observed dose with the AA genotype