Table 1.

Biological properties, bioactivities, and effects in animal models documented for lanthionine ketimine and its ethyl ester (LKE).

Activity	Reference
bound CRMP2 (DPYSL2)	58
bound syntaxin binding protein 1 (STXBP1)	58
bound LanCL1	58
bound synaptosomes (saturable, nM affinity)	45
antioxidant	58, 60
anti-neuroinflammatory (microglia)	58, 60
anti-proliferative	64
neuroprotective	58, 60
neurotrophic (neurite promoting) activity	58–59, 62, this work
suppressed amyloid peptide production	63

Effects in animal models	Reference
Alzheimer’s disease (3xTg-AD model)	63
amyotrophic lateral sclerosis (SOD1G93A model)	5
neurodevelopmental defect (Unc-33 hypomorph modeling partial loss of CRMP2)	62
ischemic stroke (pMCAO mouse model)	60