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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Cell Physiol. 2015 Apr;230(4):791–801. doi: 10.1002/jcp.24804

Figure 6. Proposed model for the coupling of RA-dependent transcription and splicing by Acinus.

Figure 6

(A) Recruitment of coactivators and the accompanying recruitment of splicing factors responsible for RA-dependent splicing activity of Acinus in the presence of RA to RARE containing promoter. (B) The pre-initiation complex formed at the RARE-containing promoter. (C) Acinus travels with the elongation complex to facilitate the recognition of weak 5′ss. Solid arrow, direct protein-protein interactions; Dashed arrow, direct or indirect interactions.