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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Hepatology. 2014 Nov 25;61(1):200–213. doi: 10.1002/hep.27396

Fig. 3.

Fig. 3

AKT/Ras induces liver tumor formation in the presence of 4EBP1A4 after long latency. (A) Gross images of AKT/Ras/4EBP1A4 injected mouse livers 21 W.P.I. (B) HE images of a small hepatocellular carcinoma (left) and a mixed hepatocellular-cholangiocellular tumor (right, arrow indicates ductular features), (C) Ki-67, HA-AKT, V5-4EBP1A4, (D) p-AKT, p-ERK, and p-mTOR staining in the liver tumors developed in AKT/Ras/4EBP1A4 injected mice. Magnifications: 400× (HE and Ki67); 200× (HA, V5, p-AKT, p-ERK, p-mTOR). 220×168mm (300 × 300 DPI)