Fig. 5.
Ablation of Raptor completely inhibits AKT/Ras hepatocarcinogenesis. (A) Gross images of livers, (B) survival curve, (C) liver weight and liver to body weight ratio of AKT/Ras/pT3 or AKT/Ras/Cre injected Raptorfl/fl mice. Data are presented as mean ± SEM. ****P<0.0001; ns: not significant. (D) HE images and HA-AKT staining in AKT/Ras/pT3 injected Raptorfl/fl mouse liver. The arrow indicates a mitotic figure within an HCC. (E) HE image and HA-AKT staining in AKT/Ras/Cre injected Raptorfl/fl mice. Magnifications: 40× (upper panel); 400× (lower panel). 167×223mm (300 × 300 DPI)
