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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Hepatology. 2014 Nov 25;61(1):200–213. doi: 10.1002/hep.27396

Fig. 7.

Fig. 7

eIF4E and Ras co-expression in liver induces hepatocarcinogenesis in mice. (A) Macroscopic appearance of eIF4E/Ras-injected mouse liver 30 weeks after hydrodynamic injection. (B) HE image and Ki67 staining, (C) HA-eIF4E, ENTPD5, CMPK1, AK1, (D) p-AKT, p-mTOR, p-RPS6, and p-ERK1/2 staining in eIF4E/Ras-injected mouse liver 30 weeks after hydrodynamic. Tu: hepatocellular tumors; the dotted line marks the tumor area. Arrows indicate preneoplastic areas. Magnifications: 20× (first HE image in B); 40× (all remaining images); 400× (inset). 239×141mm (300 × 300 DPI)