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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Bone Miner Res. 2015 Jan;30(1):83–94. doi: 10.1002/jbmr.2320

Fig. 4. A comparison of various combinations of hMSCs, OEhMSCs with GF or BGF for healing a critical-sized segmental defect of the femur.

Fig. 4

MSCs were directly administered to constructs (GF or BGF) in the presence of clotting plasma and allowed to heal for 3 weeks. Panel A: λCT scans and axial reconstructions presented as in Fig. 2A. Panel B: defect bridging defined by the presence of contiguous uninterrupted bone between the original edges of the defect. Statistics, Fisher Exact test (P<0.05=*). Panels C–E: Measurements of new bone volume (panel C), new bone surface area (panel D) and J measurements at the midline of the defect (panel E) and mean J for the entire ROI (panel F). Statistical testing was performed by ANOVA and Tukey post-test. P-values key: P<0.05 = *, P<0.01=**, P<0.005=***.