Skip to main content
. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Neuromolecular Med. 2014 Dec;16(4):686–696. doi: 10.1007/s12017-014-8318-6

Fig. 6.

Fig. 6

Correlation between brain lipoprotein receptor shedding and Aβ clearance across the BBB in apoE transgenic mice. LRP1 and LDLR levels in the soluble fraction of the brain were plotted versus the appearance of Aβ in the plasma (i.e., Aβ BBB clearance) following intracerebral Aβ administration (LRP1, R2 = 0.94; LDLR, R2 = 0.96). The Aβ BBB clearance data was derived from our previously published work (Bachmeier et al. 2013). Values represent the mean of 6 animals for each genotype. p < 0.05 for both LRP1 and LDLR as determined by Pearson correlation.